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In Vitro Studies with Miconazole and Miconazole Nitrate

  • Smith Shadomy
  • Larry Paxton
Part of the Chemotherapy book series (CT, volume 6)

Summary

The in vitro activity of miconazole and miconazole nitrate against a variety of pathogenic and saprophytic fungi was studied using an agar dilution procedure. 28 dimorphic pathogens were tested: Histoplasma capsulatum and Blastomyces dermatitidis were the most susceptible with inhibition of all strains at 0.5 ug/ml of either compound. Coccidioides immitis was somewhat more resistant requiring 1 or 2 ug/ml for inhibition, while 4 isolates of Sporothrix schenckii required 2 to 4 ug/ml for complete inhibition. All strains of Cryptococcus neuformans were susceptible to 1 ug/ml or less. Most strains of Candida albicans were resistant to less than 16 ug/ml; other species of Candida were inhibited by 4 ug/ml or less. Torulopsis isolates gave a range of MIC’s from 0.5 ug/ml to 16 ug/ml for inhibition. Of 15 dematiaceous isolates tested, all but two were inhibited at 4 ug/ml or less. A brief discussion of the possible clinical usefulness of miconazole is given.

Keywords

Candida Species Aspergillus Species Saprophytic Fungus Pathogenic Yeast Nitrate Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Smith Shadomy
    • 1
  • Larry Paxton
    • 1
  1. 1.Division of Infectious Diseases, Dept. of Medicine, School of Medicine, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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