Polyenes: Actions and Prospects
The essential requirement for the successful treatment of a microbial infection is that there should be at least one significant difference between the host and the parasite to provide a site for antibiotic action. This is clearly illustrated for bacterial (prokaryotic) infections where, for example, peptidoglycan synthesis and 70S ribosome-mediated protein synthesis are selectively inhibited by penicillin and chloramphenicol respectively. The situation for fungal infections is complicated by the fact that both parasite and host are eukaryotic organisms and the metabolic and structural differences which might provide a basis for chemotherapeutic attack result from variations on the same basic theme (Table 1).
KeywordsGeneral Microbiology Aqueous Pore Superficial Fungal Infection Peptidoglycan Synthesis Polyene Antibiotic
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