Review of Amphotericin B
Many of the important biologic properties of amphotericin B may be ascribed to binding by certain sterols in fungal and mammalian cell membranes. Avid binding to serum proteins, probably coupled at least in part by cholesterol, makes amphotericin B equilibrate slowly with infected exudates and penetrate poorly into cerebrospinal fluid, urine and hemodialysis baths. Despite toxicity and unfavorable pharmacokinetics, the drug is still the most useful agent against most systemic mycoses.
KeywordsInvasive Aspergillosis Renal Tubular Acidosis Systemic Mycosis Artificial Kidney Mammalian Cell Membrane
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