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The Efficiency of Metronidazole ‘Flagyl’* Against Trypanosoma Evansi in vivo

  • A. M. Mandour
  • A. M. Abd-El Rahman
Part of the Chemotherapy book series (CT, volume 6)

Abstract

Trypanosoma evansi is the cause of an important disease in camels known as Surra. This parasite might also be the cause of an acute and fatal disease in horses and dogs, while the infection results in a chronic disease in donkeys and transient in cattle. (Levine, 1961). According to Chandler and Read (1961) animals were formerly treated, with only fair success, with antimony compounds and antrypol, but recently two new drugs, dimidium bromide (Phenanthridium) and antrycide in the form of methyl sulphate or chloride salts, have greatly brightened the picture. However, antrycide is less effective against Trypanosoma brucei. T.evansi and T. equiperdum. On the other hand, dimidium bromide is ineffective against T.brucei, T.evansi and T.simiae.

Keywords

Blood Film Chloride Salt Blood Stage Entamoeba Histolytica Trypanosoma Brucei 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chandler, C. and Read, C.P. (1961) Introduction to Parasitology with special reference to the parasites of man. Wiley International Edition. Toppan Company, Tokyo, Japan.Google Scholar
  2. Goodman, L.S. and Gilman, A. (1968) The Pharmacological basis of therapeutics. Third edition. The McMillan Co., New York.Google Scholar
  3. Levine, N.D. (1961) Protozoan parasites of domestic animals and of man. First edition. Burgess Pnblishing Co., Minneapolis, Minnesota, U.S.A.Google Scholar
  4. Ormerod, W.E. (1951) A study of basophilic inclusion bodies produced by chemotherapeutic agents in trypanosomes. Brit. J. Pharm., 6, 334–341.Google Scholar
  5. Ormerod, W.E. (1975) Personal communication, London July 1975.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • A. M. Mandour
    • 1
  • A. M. Abd-El Rahman
    • 1
  1. 1.Department of Parasitology, Faculty of MedicineAssiut UniversityEgypt

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