Results of the Anti-T. Cruzi Activity of Ro 07-1051* IN Man
The anti-Trypanosoma cruzi activity of the compound Ro 07–1051 (N-benzyl-2-nitro-l-imidazoleacetamide) was investigated in 107 acute Chagas’ disease cases. The dosage used was 3 up to 10 mg/Kg per day for a one month period. Sero-parasitological follow up tests were performed monthly and results of a 12 months follow up are available for 76 cases. The xenodiagnosis became negative in 45 (83.3%) children and 8 (36.4%) infants and both the complement fixation test and indirect haemaglutination test decreased the positivity significantly. Immunofluorescence tests showed negative reactions or a significant decrease of the titres in successfully treated patients. Skin reactions were observed in 14% of the patients.
KeywordsSkin Reaction Negative Reaction Disease Case Acute Case Chronic Case
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