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Results of the Anti-T. Cruzi Activity of Ro 07-1051* IN Man

  • Jose A. Cerisola
  • Carlos A. Barclay
  • Humberto Lugones
  • Oscar Ledesma
Part of the Chemotherapy book series (CT, volume 6)

Abstract

The anti-Trypanosoma cruzi activity of the compound Ro 07–1051 (N-benzyl-2-nitro-l-imidazoleacetamide) was investigated in 107 acute Chagas’ disease cases. The dosage used was 3 up to 10 mg/Kg per day for a one month period. Sero-parasitological follow up tests were performed monthly and results of a 12 months follow up are available for 76 cases. The xenodiagnosis became negative in 45 (83.3%) children and 8 (36.4%) infants and both the complement fixation test and indirect haemaglutination test decreased the positivity significantly. Immunofluorescence tests showed negative reactions or a significant decrease of the titres in successfully treated patients. Skin reactions were observed in 14% of the patients.

Keywords

Skin Reaction Negative Reaction Disease Case Acute Case Chronic Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barclay, C.A., Cerisola, J.A., Lugones, H., Ledesma, O. and Jozami, L.B. (1974) Proceedings of the XIVth International Congress of Pediatrics, Buenos Aires, 4, 238.Google Scholar
  2. Lugones, H., Rabinovich, B., Cerisola, J.A., Ledesma, O. and Barclay, C.A. (1974) Third International Congress of Parasitology, Munich, 25–31 August.Google Scholar
  3. Richie, R. (1973) Ninth International Congress on Tropical Medicine and Malaria, Athens, 14–21 October.Google Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Jose A. Cerisola
    • 1
  • Carlos A. Barclay
    • 1
  • Humberto Lugones
    • 1
  • Oscar Ledesma
    • 1
  1. 1.Instituto Nacional de Diagnostico e Investigacion de la Enfermedad de Chagas ‘Dr.M.F.Chaben’Buenos AiresArgentina

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