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Microbiology of Carfecillin, The α-Phenyl Ester of Carbenicillin

  • M. J. Basker
  • R. Sutherland
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Carbenicillin (α-carboxybenzylpenicillin) is a broad spectrum penicillin active against a wide range of bacteria including Pseudomonas aeruginosa and is widely used in the treatment of serious infections caused by pseudomonas or other Gran-negative bacilli. Carbenicillin is poorly absorbed by the oral route and is effective only after parenteral administration, but certain α-esters of the compound are absorbed after oral administration and undergo hydrolysis in the body to liberate carbenicillin (English et al, 1972; Clayton et al, 1975). This report describes the in vitro activity of one such ester, carfecillin.

Keywords

Antibacterial Activity Minimum Inhibitory Concentration Parenteral Administration Standard Line Agar Diffusion Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Clayton, J. P., Cole, M., Elson, S. W., Hardy, K. D., Mizen, L. W., and Sutherland, R. 1975. J. Med. Chem., 18, 172.PubMedCrossRefGoogle Scholar
  2. English, A. R., Retsema, J. A., Ray, V. A., and Lynch, J. G. 1972. Antimicrob. Ag. Chemother., 1, 185.Google Scholar
  3. Wilkinson, P. J., Reeves, D. S., Wise, R., and Allen, J. T. 1975. Brit. Med. J., 2, 250.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. J. Basker
    • 1
  • R. Sutherland
    • 1
  1. 1.Beecham Pharmaceuticals Research DivisionBetchworth, SurreyEngland

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