Microbiology of Carfecillin, The α-Phenyl Ester of Carbenicillin
Carbenicillin (α-carboxybenzylpenicillin) is a broad spectrum penicillin active against a wide range of bacteria including Pseudomonas aeruginosa and is widely used in the treatment of serious infections caused by pseudomonas or other Gran-negative bacilli. Carbenicillin is poorly absorbed by the oral route and is effective only after parenteral administration, but certain α-esters of the compound are absorbed after oral administration and undergo hydrolysis in the body to liberate carbenicillin (English et al, 1972; Clayton et al, 1975). This report describes the in vitro activity of one such ester, carfecillin.
KeywordsAntibacterial Activity Minimum Inhibitory Concentration Parenteral Administration Standard Line Agar Diffusion Test
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