Abstract
Cinoxacin, a synthetic organic compound with cinnoline(1–2 benzodiazine) as the basic ring structure has been shown to have a broad antibacterial spectrum, particularly against gram negative bacteria that are most frequently isolated from the urinary tract (1). Administered orally the compound was bactericidal at concentrations close to the minimal inhibitory concentration values. In vivo, doses required for successful therapy were comparable to those for nalidixic acid. Cinoxacin is less bound by human serum proteins than nalidixic acid, has similar antibacterial activity but appears to cause less resistence after treatment.
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References
Wick, N.E., Preston, D.A., Wgite, W.A. and Gordee, R.S. Compound 64716, A New Synthetic Antibacterial Agent. Antimicrobial Agents and Chemotherapy, 4: 415, 1973.
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© 1976 Plenum Press, New York
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Bennett, A.H. (1976). The Use of Cinoxacin in Urinary Tract Infections. In: Williams, J.D., Geddes, A.M. (eds) Penicillins and Cephalosporins. Chemotherapy, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3126-1_67
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DOI: https://doi.org/10.1007/978-1-4684-3126-1_67
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3128-5
Online ISBN: 978-1-4684-3126-1
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