Advertisement

In Vitro and in Vivo Studies on Antibiotics from Skin Micrococcaceae

  • S. Selwyn
  • P. D. Marsh
  • Tushna N. Sethna
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Primary skin cultures from 1,320 individuals — including 790 healthy people — yielded 173 strains of Micrococcaceae species which possessed considerable antibacterial activity. Inoculation of these antagonistic organisms on to background lawns of representative Gram-positive and Gram-negative bacteria revealed widely varying ranges and degrees of inhibitory effects. Antagonistic strains of Staphylococcus aureus were chiefly confined to bacteriophage Group II and had a narrow spectrum of action limited mainly to Corynebacterium and Streptococcus species. Coagulase-negative staphylococci and micrococci, however, included strains with broad antibacterial spectra. A particularly active and stable inhibitory strain of Staph. epidermidis (biotype 4) was isolated from the forehead of one of us (S.S.). This organism (referred to as ‘S6+’) was selected for detailed investigation.

Keywords

Zinc Chloride Streptococcus Species Broad Antibacterial Spectrum Skin Bacterium Antagonistic Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Selwyn, S., & Ellis, H., (1972), Skin bacteria and skin disinfection reconsidered, Br. med. J., 1, 136.PubMedCrossRefGoogle Scholar
  2. 2.
    Selwyn, S. (1975), Natural antibiosis among skin bacteria as a primary defence against infection, Br. J. Derm., 92, in press.Google Scholar
  3. 3.
    Anthony, B. F., & Wannamaker, L. W., (1967), Bacterial interference in experimental burns, J. exp. Med., 125, 319.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • S. Selwyn
    • 1
  • P. D. Marsh
    • 1
  • Tushna N. Sethna
    • 1
  1. 1.Department of BacteriologyWestminster Medical SchoolLondonUK

Personalised recommendations