In Vitro and in Vivo Studies on Antibiotics from Skin Micrococcaceae
Primary skin cultures from 1,320 individuals — including 790 healthy people — yielded 173 strains of Micrococcaceae species which possessed considerable antibacterial activity. Inoculation of these antagonistic organisms on to background lawns of representative Gram-positive and Gram-negative bacteria revealed widely varying ranges and degrees of inhibitory effects. Antagonistic strains of Staphylococcus aureus were chiefly confined to bacteriophage Group II and had a narrow spectrum of action limited mainly to Corynebacterium and Streptococcus species. Coagulase-negative staphylococci and micrococci, however, included strains with broad antibacterial spectra. A particularly active and stable inhibitory strain of Staph. epidermidis (biotype 4) was isolated from the forehead of one of us (S.S.). This organism (referred to as ‘S6+’) was selected for detailed investigation.
KeywordsZinc Chloride Streptococcus Species Broad Antibacterial Spectrum Skin Bacterium Antagonistic Strain
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