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Clinical Studies of Pipemidic Acid in the Field of Pediatrics

  • Susumu Nakasawa
  • Ei Tanaka
  • Hajime Sato
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Pipemidic acid (1) is a new synthetic antibacterial agent having a pyridopyrimidine ring which follows piromidic acid (2). Their chemical structures are shown in Fig. 1. Compared to analogous agents like piromidic acid and nalidixic acid (3), it has some interesting chemotherapeutic properties such as excellent antibacterial potency against gram-negative organisms including Pseudomonas aeruginosa and bacteria resistant to nalidixic acid, oral efficacy on experimental animal infections due to gram-negative bacteria including Pseudomonas aeruginosa, which is generally higher than the effect of piromidic acid, nalidixic acid, cephalexin, ampicillin and carbenicillin, and good distribution to tissues, whose levels are generally higher than the plasma level.

Keywords

Pseudomonas Aeruginosa Nalidixic Acid Serratia Marcescens Neisseria Meningitidis Agar Dilution Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

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    Matsumoto, J. and S. Minami: Pyrido(2,3-d)pyrimidine antibacterial agents. 3. 8-Alkyl-and 8-vinyl-5,8-dihydro-5-oxo-2- (1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acids and their derivatives. J. Med. Chem. 18: 74–79, 1975.PubMedCrossRefGoogle Scholar
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    Shimizu, M, S. Nakamura and Y. Takase: Piromidic acid, a new antibacterial agent: Antibacterial properties. Antimicrob. Agents Chemother. 1970, 117–122, 1971.Google Scholar
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    Lesher, G. Y., E. J. Froelich, M. D. Gruett, J. H. Bailey and R. P. Brundage: 1,8-Naphthyridine derivatives. A new class of chemotherapeutic agents: J. Med. Pharm. Chem. 5: 1063–1065, 1962.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Susumu Nakasawa
    • 1
  • Ei Tanaka
    • 1
  • Hajime Sato
    • 1
  1. 1.Clinic of Pediatrics, Tokyo Metropolitan Ebara Hospital and Department of PediatricsShowa University School of MedicineTokyoJapan

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