Effect of Primycin on DNA
The antibiotic primycin in 100 μM concentration almost completely inhibits the temolate function of 100 μM poly/dA-dT/, poly/dG-dC/, poly/dA/, natural phage DNA or calf thymus DNA in enzyme mixture containing E. coli RNA polymerase in excess. The inhibition occures mainly during elongation. The primycin has a similar inhibitory effect in the case of E.coli DNA polymerase I. investigated with different templates.
KeywordsPropylene Glycol Polymerase Activity Enzyme Mixture Double Stranded Form Tryptophan Pyrrolase
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- Arndt-Jovin,D.J., Jovin,T.M., Bahr,W., Frischauf,A-M. and Marquardt,M. /1975/, in pressGoogle Scholar