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Pharmacological and Clinical Studies with Talampicillin, an Ester of Ampicillin

  • P. J. Wilkinson
  • A. L. Thomas
  • D. S. Reeves
  • J. Symonds
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Talampicillin (Talpen, Beecham Research Laboratories) is the thiazolidine carboxylic ester of ampicillin. After oral administration the ester is rapidly hydrolysed in the intestinal wall to release free ampicillin into the body (Jeffery et al, 1975). We initially did some studies in human volunteers to confirm the findings of Clayton et al (1974) that talampicillin gives higher blood levels than the same oral doses of ampicillin. A study was then undertaken in patients with infections from ampicillin-sensi-tive organisms to assess the pharmacology and clinical effectiveness of talampicillin.

Keywords

Urinary Infection Chest Infection High Blood Level Urinary Tract Pathology Thiazolidine Carboxylic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Clayton, J.P. Cole, M., Elson, S.W. Ferres, H. (1974). Antimicrobial Agents and Chemotherapy, 5, 670.PubMedGoogle Scholar
  2. Jeffery, D.J., Jones, K.H., Langley, P.F. (1975). IXth International Congress of Chemotherapy.Google Scholar
  3. Knudsen, E.T. Harding, J.H. (1975). IXth International Congress of Chemotherapy.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. J. Wilkinson
    • 1
  • A. L. Thomas
    • 1
  • D. S. Reeves
    • 1
  • J. Symonds
    • 1
  1. 1.Department of Medical MicrobiologySouthmead HospitalBristolEngland

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