Interactions of New Cephalosporins with Some Cephalosporinases

  • Roger Labia
Part of the Chemotherapy book series (CT, volume 5)


Bacterial strains resistant to one, or few, ß lactam antibiotics generally produce ß lactamases which are the enzymes able to cleave an amide bond in penicillins and cephalosporins and make the penicilloic thus obtained completely inactive. Recently Richmond and Sykes (1973) reported a classification of ß lactamases essentialy based on the profile of activity of these enzymes on various substrates and reaction with various inhibitors.


Bacterial Strain Minimal Inhibitory Concentration Pseudomonas Aeruginosa Amide Bond Bacterial Resistance 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Roger Labia
    • 1
  1. 1.Ecole Normale Superieure (ER 156 CNRS)Paris Cedex 05France

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