Beta-Lactamase Resistance of Cephazolin and Other Cephalosporins
During the first few hours of interaction between an antibiotic and a bacterial culture different changes may occur with strains that have similar minimal inhibitory concentrations of that antibiotic. Continuous turbidimetric monitoring of cultures of bacteria in the biophotometer is particularly suitable for recording the interaction between ß -lactam antibiotics and bacteria that produce (ß-lactamases. We have studied the activity of some cephalosporins in the biophotometer relating the results to the MICs for dense populations of bacteria, and to the exact concentration of organisms at the time of addition of the antibiotic.
KeywordsType IlIa Lactam Antibiotic Antibiotic Addition Large Inoculum Northwick Park Hospital
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