Advertisement

Substrate Profiles of β-Lactamases Against Newer β-Lactam-antibiotics

  • B. Wiedemann
  • V. Krcmery
  • H. Knothe
Part of the Chemotherapy book series (CT, volume 5)

Abstract

In recent years it has become common to classify enzymes of gram-negative bacteria, which inactivate β-lactam-antibiotics, by means of their substrate profiles, i.e. their relative activity towards a set of substrates (β-lactam-antibiotics). One such classification which acquired a general recognition is that of Jack and Richmond. However several new derivatives of both semisynthetic Penicillins and cephalosporins have been introduced since. Therefore it seems important to investigate the possible application of substrate profiles to evaluate the relative stability of some newly introduced substances towards β-lactamase, which are mostly coded by R-factors from hospital strains in the Frankfurt area.

Keywords

Resistant Strain Serratia Marcescens Coli Group General Recognition Resistance Penicillin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. Wiedemann
    • 1
  • V. Krcmery
    • 1
  • H. Knothe
    • 1
  1. 1.Institut für Medizinische MikrobiologieUniversität FrankfurtWest Germany

Personalised recommendations