Substrate Profiles of β-Lactamases Against Newer β-Lactam-antibiotics
In recent years it has become common to classify enzymes of gram-negative bacteria, which inactivate β-lactam-antibiotics, by means of their substrate profiles, i.e. their relative activity towards a set of substrates (β-lactam-antibiotics). One such classification which acquired a general recognition is that of Jack and Richmond. However several new derivatives of both semisynthetic Penicillins and cephalosporins have been introduced since. Therefore it seems important to investigate the possible application of substrate profiles to evaluate the relative stability of some newly introduced substances towards β-lactamase, which are mostly coded by R-factors from hospital strains in the Frankfurt area.
KeywordsResistant Strain Serratia Marcescens Coli Group General Recognition Resistance Penicillin
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