Absorption and Excretion Studies of Cephalosporins in Human Subjects

  • A. G. Paradelis
Part of the Chemotherapy book series (CT, volume 5)


Brotzu (1948) showed that filtrates of the fungus Cephalosporium acremonium had strong antibiotic activity against many gram-negative and gram-positive bacteria. Further investigation revealed that this fungus contained three distinct antibiotics.One of these was labeled cephalosporin C and was of special interest because of its action on penicillin-resistant staphylococci and gram-negative organisms.


Intravenous Injection Urine Concentration Peak Serum Level Human Serum Protein Excretion Study 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. G. Paradelis
    • 1
  1. 1.Department of Experimental Pharmacology, Medical FacultyAristotelian University of ThessalonikiThessalonikiGreece

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