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A New Parenteral Cephalosporin. SK&F 59962: Serum Levels and Urinary Recovery in Man

  • Paul Actor
  • Donald H. Pitkin
  • George Lucyszyn
  • Jerry A. Weisbach
  • José L. Bran
Part of the Chemotherapy book series (CT, volume 5)

Summary

The pharmacokinetic profile of SK&F 59962, a new parenteral cephalosporin, was found to be similar to that of cephalothin after intravenous or intramuscular administration to human volunteers. SK&F 59962 was well-tolerated when administered parenterally. No overt pain was observed in 15 of 17 subjects after intramuscular administration of SK&F 59962 in contrast to cephalothin where pain was observed in all of the subjects following intramuscular administration.

Keywords

Intramuscular Administration Urinary Recovery Guatemala City Serum Curve Adult Male Volunteer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Actor, P. A., Uri, J. V., Guarini, J. R., Zajac, I., Phillips,L., Sachs, C. S., DeMarinis, R. M., Hoover, J. R. E. and Weisbach, J. A. (1975), J. Antibiotics, 28, 471.CrossRefGoogle Scholar
  2. Cahn, M. H., Levy, E. J., Actor, P. and Pauls, J. F. (1974), J. Clin. Pharmacol., 14, 61.PubMedGoogle Scholar
  3. DeMarinis, R. M., Hoover, J. R. E., Dunn, G. L., Actor, P., Uri, J. V. and Weisbach, J. A. (1975), J. Antibiotics, 28, 463.CrossRefGoogle Scholar
  4. Fare, L. R., Actor, P., Sachs, C. S., Phillips, L., Joloza,M., Pauls, J. F. and Weisbach, J. A. (1974), Antimicr. Agents Chemother., 6, 150.Google Scholar
  5. Hattie, E. S and Ravin, L. J. (1975), Antimicr. Agents Chemother., 7, 606.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Paul Actor
    • 1
  • Donald H. Pitkin
    • 1
  • George Lucyszyn
    • 1
  • Jerry A. Weisbach
    • 1
  • José L. Bran
    • 2
  1. 1.Smith Kline & French LaboratoriesPhiladelphiaUSA
  2. 2.Hospital General San Juan de DiosGuatemala CityGuatemala C.A.

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