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The Activity of Mecillinam (FL1060), in Combination with Other Antibiotics, Against H. Influenzae and Streptococcus Faecalis

  • R. Wise
  • G. A. J. Ayliffe
  • J. M. Andrews
  • K. A. Bedford
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Mecillinam, a member of a new group of ß-lactam antibiotics, the 6 — ß amidinopenicillanic acids, has considerable activity against the Enterobacteriacae (Lund & Tybring, 1972). This drug has little activity against the Gram positive organisms and its activity against Haemophilus influenzae has not been fully explored. This study was designed to see if any clinically useful synergistic combinations of other antibiotics together with mecillinam could be found.

Keywords

Minimum Inhibitory Concentration Haemophilus Influenzae Fusidic Acid Fractional Inhibitory Concentration Synergistic Combination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bushby, S.R.M. Trimethoprim–Sulphamethoxazole: In vitro Microbiological aspects. Journal of Infectious Diseases 128: S442–462 (1973).CrossRefGoogle Scholar
  2. Elion, G.B., Singer, S., Hitchings, G.H. Antagonists of nucleic acid derivative. Journal of Biological Chemistry 208: 477–488 (1954).PubMedGoogle Scholar
  3. Wise, R., and Reeves, D.S. In Press (1975).Google Scholar
  4. Tybring, L., Melchior, N.H. In Press (1975).Google Scholar
  5. Lund, F. and Tybring, L. 6 ß-amidinopenicillanic acid acids–a new group of antibiotics. Nature, New Biology 236: 135–137 (1972).Google Scholar
  6. Melchior, N.H., Blom. J., Tybring, L. and Birch-Anderson, A. Light and Electron Microscopy of the early response of E. coli to a 6 ß3-amidinopenicillanic acid (FL1060). Acta. Path. Microbiol. Scand. 81B: 393–407 (1973).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. Wise
    • 1
  • G. A. J. Ayliffe
    • 1
  • J. M. Andrews
    • 1
  • K. A. Bedford
    • 1
  1. 1.Department of Medical MicrobiologyDudley Road HospitalBirminghamUK

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