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Mecillinam: Factors Affecting in Vitro Activity

  • D. S. Reeves
  • R. Wise
  • M. J. Bywater
  • S. R. Stern
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Mecillinam (FL.1060, Leo Laboratories; 6B-(hexahydro-1Hazepin-l-yl)-methyleneamino-penicillanic acid) is a new class of semi-synthetic penicillin derivatives characterised by the presence of a 6B-amidino substitution in the penicillanic acid nucleus. Preliminary studies indicated a high degree of activity against Gram negative bacteria (Lund and Tybring, 1972). It was decided therefore to assess the activity of mecillinam in the laboratory particularly with a view to its use in infections of the urinary tract.

Keywords

Inoculum Size Proteus Mirabilis Vitro Activity Factor Affecting Penicillanic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Lund, F., and Tybring, L. Nature New Biology 236, 135–136 (1972).PubMedGoogle Scholar
  2. Greenwood, D., and O’Grady, F. J. Clin.Path. 26, 1–6 (1973).PubMedCrossRefGoogle Scholar
  3. Greenwood, D., Brooks, H.L., Gargan, R., and O’Grady, F. J. Clin. Path. 27, 192 - 197 (1974).CrossRefGoogle Scholar
  4. Reeves, D.S., Wise, R., and Bywater, M.J. Journal of Antimicrobial Chemotherapy, 1974 (in press).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • D. S. Reeves
    • 1
  • R. Wise
    • 1
  • M. J. Bywater
    • 1
  • S. R. Stern
    • 1
  1. 1.Department of Medical MicrobiologySoutemead HospitalBristolUK

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