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Plasma Profile & Urinary Excretion of Mecillinam after Pivmecillinam

  • R. L. Parsons
  • Gillian M. Hossack
  • Gillian M. Paddock
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Pivmecillinam (F.L. 1039. Leo) is the pivaloyloxymethyl ester of mecillinam (F.L. 1060. Leo). Like the related pivampicillin, which is the pivaloyloxy methyl ester of ampicillin, pivmecillinam is biologically inactive Until in-vivo hydrolysis to its biologically active constituent mecillinam. These reactions are shown in Fig. 1.

Keywords

Coeliac Disease Plasma Profile Pancreatic Exocrine Function Dihydrogen Potassium Phosphate Amino Benzyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Parsons, R.L., Bywater, M.J. and Marshall, M. (1974) The absorption of cephalexin and three aminobenzylpenicillins in adult coeliac disease. Progress in Chemotherapy. Proceedings of the 8th International Congress of Chemotherapy. (1973). Vol 1. 534–542. Edit. G. Daikos. Published by the Hellenic Society for Chemotherapy. Athens.Google Scholar
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    Lundh, G. (1962) Pancreatic exocrine function in neoplastic and inflammatory disease, A simple and reliable new test. Gastroenterology. 44, 588–597.Google Scholar
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    Parsons, R.L. Hossack, G.M. and Paddock, G.M. (1975) Absorption of aminobenzylpenicillins and cephalexin in normal subjects whilst starved and with a Lundh test meal. Journal of Antimicrobial Chemotherapy. 2, in press.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. L. Parsons
    • 1
  • Gillian M. Hossack
    • 1
  • Gillian M. Paddock
    • 1
  1. 1.Dept. Clinical PharmacologyGuy’s Hospital Medical SchoolLondonUK

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