Bacampicillin in Acute Tonsillitis
Bacampicillin was evaluated in 58 patients with acute tonsillitis. Patients were assigned randomly to receive either 200, 400, 600 or 800 mg three times daily for 10 days. Initial cultures were positive for β-haemolytic streptococci in 32 of 57 cases (56%). The cure rate was 97% at follow-up after three weeks. Two patients were considered as therapeutic failures clinically. In one of them all bacteriological cultivations yielded indigenous growth. In the other patient the initial cultivation yielded (3-haemolytic streptococci, which, however, could not be isolated at control after one and three weeks.
The aim of this investigation was to gain information of the dose-response relationships regarding efficacy and tolerance in treatment with bacampicillin administered orally.
Bacampicillin is an ester of ampicillin (fig. 1) which is resorbed rapidly and almost completely (fig. 2) and is re-transformed to ampicillin at absorption.
These circumstances diminish to a high degree the risk for gastro-intestinal disturbances and also give a higher concentration in serum than that achieved with non-esterified ampicillin.
KeywordsBacterial Cultivation Blood Agar Initial Cultivation Horse Blood Acute Tonsillitis
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