Clinical Relevance of Ampicillin/Cloxacillin for IV Use
Most of the gram negative bacilli (especially enterobacteriaceae) which are highly resistant to ampicillin (A) produce penicillinases which inactivate the antibiotic by hydrolyzing the beta-lactam ring. It has been postulated that the adjunction of an inhibitor of betalactamases would block the enzymes and allow therefore undestroyed A to exert a more prolonged bactericidal effect on apparently A resistant strains. Cloxacillin (C) is one of these inhibitors of penicillinases produced by E. coli, Klebsiella, Proteus sp., E. cloacae and Ps. aeruginosa. It exerts its inhibitory effect by a marked affinity for the beta-lactamases and forms relatively stable enzyme substrate complexes (1–3).
KeywordsZone Size Susceptible Strain Negative Bacillus Average Serum Concentration Klebsiella Strain
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