Clinical Relevance of Ampicillin/Cloxacillin for IV Use

  • C. Regamey
  • L. Barrelet
  • F. A. Waldvogel
Part of the Chemotherapy book series (CT, volume 5)


Most of the gram negative bacilli (especially enterobacteriaceae) which are highly resistant to ampicillin (A) produce penicillinases which inactivate the antibiotic by hydrolyzing the beta-lactam ring. It has been postulated that the adjunction of an inhibitor of betalactamases would block the enzymes and allow therefore undestroyed A to exert a more prolonged bactericidal effect on apparently A resistant strains. Cloxacillin (C) is one of these inhibitors of penicillinases produced by E. coli, Klebsiella, Proteus sp., E. cloacae and Ps. aeruginosa. It exerts its inhibitory effect by a marked affinity for the beta-lactamases and forms relatively stable enzyme substrate complexes (1–3).


Zone Size Susceptible Strain Negative Bacillus Average Serum Concentration Klebsiella Strain 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • C. Regamey
    • 1
  • L. Barrelet
    • 1
  • F. A. Waldvogel
    • 1
  1. 1.Infectious Disease DivisionDepartment of Medicine Hôpital cantonalGeneva 4Switzerland

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