Oral Treatment with Carindacillin in Patients Suffering from Urinary Tract Infections
As is well known, the antibiotic carbenicillin has been used for some time in the treatment of urinary tract infections supported by Escherichia coli, Proteus and especially by Pseudomonas aeruginosa. However, up till now this drug could not be administered by oral route because it was available only in its sodic form which is unstable at acid values of pH (Renzini and Ferri 1974, Butler et al 1970). The relatively recent synthesis of an acid-stable indanyl ester of carbenicillin has made it possible to administer the antibiotic orally, in that this compound (indanyl carbenicillin) is readily absorbed from the ggastroenteric mucous membrane (Bailey 1972, Butler et al 1973).
KeywordsUrinary Tract Infection Pseudomonas Aeruginosa Urine Culture Oral Treatment Therapeutic Effectiveness
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