Indanyl Carbenicillin and Urinary Infections
Indanyl carbenicillin’s activity is widely known. Carbenicillin indanyl sodium is a derivative of alpha-carboxybenzylpenicillin (carbenicillin) that in its turn is a new broad-spectrum semisynthetic penicillin to which a considerable effectiveness against Pseudomonas and Proteus is attributed (English and Evangelisti 1973, Standiford et al 1968). Indanyl carbenicillin is stable in an acid environment and can therefore be used by oral route; it is rapidly absorbed and metabolized, causing the formation of carbenicillin and indanyl metabolites (Bo et al 1972, Kayser et al 1973). The spectrum of action of carbenicillin, and therefore also of its indanyl ester, is vast and takes in Gram-positive and Gram-negative bacteria from Escherichia to Clostridium including Proteus, Pseudomonas, etc. (Berrill et al 1973, Cox 1973). After oral administration of 1 g of indanyl carbenicillin every 6 hours, very high urinary concentrations (more than 1 mg/ml) are obtained; said concentrations are many times greater than the MIC’s relative to the germs most involved in urinary infections (Knirsch 1972).
KeywordsNalidixic Acid Oral Route Urinary Infection Clinical Failure Sterile Culture
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