Pharmacological and Clinical Studies with Carfecillin, an Orally Administered Ester of Carbenicillin
Carfecillin (Uticillin, Beecham Pharmaceuticals) is the phenyl ester of carbenicillin. The substitution of a phenyl group on the active side-chain enhances oral absorption, after which hydrolysis in the intestinal mucosa releases free carbenicillin into the circulation. The tablets of carfecillin now available commercially have been shown by Jones K.H. (1974) in healthy volunteers to give mean peak serum levels which are 37% better and 15 minutes earlier than those obtained from the formulation in gelatin capsules which was used throughout this series of studies. Details of method will not be given here, but are described elsewhere (Wilkinson P.J. et al., 1975).
KeywordsSingle Oral Dose Urinary Infection Gelatin Capsule Urethral Stricture Neurogenic Bladder
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