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Pharmacological and Clinical Studies with Carfecillin, an Orally Administered Ester of Carbenicillin

  • P. J. Wilkinson
  • D. S. Reeves
  • R. Wise
Part of the Chemotherapy book series (CT, volume 5)

Abstract

Carfecillin (Uticillin, Beecham Pharmaceuticals) is the phenyl ester of carbenicillin. The substitution of a phenyl group on the active side-chain enhances oral absorption, after which hydrolysis in the intestinal mucosa releases free carbenicillin into the circulation. The tablets of carfecillin now available commercially have been shown by Jones K.H. (1974) in healthy volunteers to give mean peak serum levels which are 37% better and 15 minutes earlier than those obtained from the formulation in gelatin capsules which was used throughout this series of studies. Details of method will not be given here, but are described elsewhere (Wilkinson P.J. et al., 1975).

Keywords

Single Oral Dose Urinary Infection Gelatin Capsule Urethral Stricture Neurogenic Bladder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Jones, K.H. (1974). Personal communication.Google Scholar
  2. 2.
    Wilkinson, P.J., D.S. Reeves, R. Wise and J.T. Allen (1975). Brit. med. J. 2, 250–252.PubMedCrossRefGoogle Scholar
  3. 3.
    Lees, L.J. and Harding, J.W. (1974). Brit. J. clin. Pract. 28, 349–352.PubMedGoogle Scholar
  4. 4.
    Reeves, D.S. (1974). Brit. med. J. 4, 718–719.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. J. Wilkinson
    • 1
  • D. S. Reeves
    • 1
  • R. Wise
    • 1
  1. 1.Department of Medical MicrobiologySouthmead HospitalBristolEngland

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