Passage of Doxycycline into the Thoracic Duct Lymph after Oral and Intravenous Administration in Man
The concentrations of doxycycline in serum and in thoracic duct lymph after oral and intravenous administration were studied in 10 patients. Oral administration of 200 mg resulted in a mean peak serum concentration of 2.4 µg/ml (n = 7) after 3 h; the levels then successively declined. The concentrations in thoracic duct lymph were lower, a mean peak concentration of 1.6 µg/ml being found 3 h and 6 h after the intake. After intravenous administration (n = 3) of 200 mg, the concentrations of doxycycline in thoracic duct lymph were lower than but closely followed those in serum. — The results suggest that doxycycline is rapidly distributed to interstitial tissue fluids.
KeywordsIntravenous Administration Thoracic Duct Tissue Fluid Peak Serum Concentration Serum Pool
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