Antibiotics in Respiratory Secretions in the Experimental Animal
The use of antimicrobial agents in the treatment of bacterial pulmonary infections has not been uniformly successful. Although certain infections, such as pneumococcal pneumonia, usually respond well to antibiotics, a discouraging record has accumulated for treatment of chronic bronchitis, bronchiectasis, certain forms of pulmonary abscesses and chronic bronchopulmonary infection in patients with cystic fibrosis. Factors which influence successful antimicrobial therapy are the immune status of the host, the virulence of the infecting organism, and importantly, the ability to achieve concentrations of antibiotic agents at the site of infection which exceed the minimum inhibitory concentration of the infecting organism. Serum antibiotic concentrations are often used to monitor for effective therapeutic levels, yet the actual site of infection may be at an anatomic location well outside the circulation. Except for highly protein-bound antibiotics, serum levels correlate closely with extravascular interstitital concentrations in many soft tissue spaces (Verwey and Williams 1962; Barza and Weinstein 1974). The intrabronchial lumen, however, is separated from the circulation by more formidable barriers, analogous perhaps to the blood-brain barrier for cerebral spinal fluid.
KeywordsMinimal Inhibitory Concentration Cerebral Spinal Fluid Pneumococcal Pneumonia Bronchial Secretion Bronchial Lumen
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- Verwey, W.F. and Williams, H.R. (1962), Antimicrob. Agents Chemother., 1961, 476.Google Scholar