In Vitro Studies of Chemical Interaction of Gentamicin or Tobramycin in Combination with Lincomycin or Clindamycin

  • H. A. Holt
  • D. S. Reeves
Part of the Chemotherapy book series (CT, volume 4)


Following the report of Meers (1973) showing the apparent inhibition of gentamicin bactericidal activity by clindamycin, and because of the increasing awareness of the possibility of infection with Bacteroides species leading to a higher frequency of the use of lincomycin or clindamycin concurrently with gentamicin, an investigation into possible chemical interaction between these drugs seemed appropriate. Interaction of gentamicin with carbenicillin leading to significant inactivation of the former Las been described (McLaughlin and Reeves 1971; Riff and Jackson, 1972), and the object of the present study was to ascertain whether a similar mutual inactivation would occur between gentamicin and lincomycin or clindamycin.


Chemical Interaction Microbiological Method Gentamicin Sulphate Klebsiella Species Bacteroides Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bennett, J.V., Brodie, J.L., Benner, E.J., and Rlrby, N.M.M. (1966). Applied Microbiology, 14, 170–177.PubMedGoogle Scholar
  2. Broughall, J.M. and Reeves, D.S. (1975). Journal of Clinical Pathology.Google Scholar
  3. McLaughlin, J.E., and Reeves, D.S. (l97l), Lancet 1, 261–264.CrossRefGoogle Scholar
  4. Meers, P.D. (1973). Lancet 2, 573.PubMedCrossRefGoogle Scholar
  5. Reeves, D.S., and Holt, H.A. (1975). J. Clin Path. 28, 435–442.PubMedCrossRefGoogle Scholar
  6. Riff, L.J., and Jackson, G.G. (1972). Archives of Internal Medicine, 130, 887–891.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. A. Holt
    • 1
  • D. S. Reeves
    • 1
  1. 1.Department of Medical MicrobiologySouthmead HospitalBristolEngland

Personalised recommendations