Advertisement

Pharmacokinetic and Pharmacological Interactions of Antibacterial Drugs

  • Edward R. Garrett
  • Peter H. Hinderling
Part of the Chemotherapy book series (CT, volume 4)

Abstract

Proper antibacterial therapy demands appropriate duration and concentration of antibacterial agents at the foci of infections in the body so that effective disinfection can occur. The necessary vital processes of the body impede the drug’s absorption, dilute it into various volumes of distribution, bind it to plasma proteins, tissues and red blood cells and remove it from the body by metabolic and excretory routes so that the drug’s effectivity is diminished.

Keywords

Dosage Regimen Pharmacokinetic Model Optimum Dosage Regimen Pharmacological Interaction Individualize Dosage Regimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Garrett, E.R., Antibiotica et Chemotherapia, Advances, 12, 149, 1964.Google Scholar
  2. 2.
    Garrett, E.R. and Alway, C.D., 3rd International Congress of Chemotherapy, Proceedings 3, 1666, 1963.Google Scholar
  3. 3.
    Garrett, E.R. and Gravenstein, J.J., Pharmacokinetic models and their use in clinical investigation, in 5th International Congress of Chemotherapy, Proceedings 4, 105, 1967.Google Scholar
  4. 4.
    Garrett, E.R., Advances in the Biosciences 5, Pergamon Press, New York, pp. 7–17, 1969.Google Scholar
  5. 5.
    Garrett, E.R., International Journal of Clinical Pharmacology, 3, 193, 1969.Google Scholar
  6. 6.
    Garrett, E.R., Theoretical pharmacokinetics, in: Klinische Pharmakologie und Pharmakotherapie, Kuemmerle, H.P., Garrett, E.R. and Spitzy, K.H. (eds.), Urban and Schwarzenberg Verlag, Munich pp. 27–40, 1971.Google Scholar
  7. 7.
    Garrett, E.R., J. Pharmacokinetics and Biopharmaceutics, 1, 341 (1973).CrossRefGoogle Scholar
  8. 8.
    Garrett, E.R., Johnston, R.L. and Collins, E.J., J. Pharm. Sci. 51, 1050, 1962.CrossRefGoogle Scholar
  9. 9.
    Garrett, E.R., Johnston, R.L. and Collins, E.J., J. Pharm. Sci. 52, 668, 1963.PubMedCrossRefGoogle Scholar
  10. 10.
    Price, H.L., Kovnat, P.J., Safer, J.N., Connor, E.H. and Price, M.L., Clin. Pharmacol. Therap., 1, l6, 1960.Google Scholar
  11. 11.
    Maren, T.H., The binding of inhibitors to carbonic anhydrase in vivo: drugs as markers for enzyme. 1st International Pharmacological Meeting, Proceedings 5, 39, 1963.Google Scholar
  12. 12.
    Garrett, E.R., Int. J. Clin. Pharmacol., 4, 6, 1970.Google Scholar
  13. 13.
    Dost, F.H., Grundlagen der Pharmakokinetik, 2nd Ed., G. Thieme Verlag, Stuttgart, 1968.Google Scholar
  14. 14.
    Krüger-Thiemer, E., 3rd International Congress of Chemotherapy, Proceedings, 1963, 2, l686, 1964.Google Scholar
  15. 15.
    Krüger-Thiemer, E., International Journal Theoretical Biology, 13, 212, 1966.CrossRefGoogle Scholar
  16. 16.
    Dettli, L., Multiple dose elimination kinetics and drug accumulation in patients with normal and impaired kidney function, in: Advances in the Biosciences 5, Raspé’, G., (ed.), Pergamon Press and Vieweg, Oxford, New York and Braunschweig, pp. 39–44 1970.Google Scholar
  17. 17.
    Garrett, E.R., Ågren, A.J. and Lambert, H.J., International J. Clin. Pharmacol., 1, 1, 1967.Google Scholar
  18. 18.
    Weinstein, L. and Dalton, A.C., New England J. Med., 279, 580, 1968.CrossRefGoogle Scholar
  19. 19.
    Holmes, B., Quie, P.G., Windhorst, D.B., Pollara, B. and Good, R.A., Nature, 210, 1131, 1966.PubMedCrossRefGoogle Scholar
  20. 20.
    Krüger-Thiemer, E., J. Amer. Pharm. Ass. Sci. Ed., 49, 3, 1960.Google Scholar
  21. 21.
    Garrett, E.R. and Won, C.M., J. Pharm. Sci., 62, l666, 1973.PubMedCrossRefGoogle Scholar
  22. 22.
    Drutz, D.J., Spichard, A., Rogers, D.E. and Koenig, M.G., Am. J. Med., 45, 405 1968.PubMedCrossRefGoogle Scholar
  23. 23.
    Klastersky, J., Daneau, D., Swings, G., and Weerts, D., J. Infect. Dis., 129, 187 (1974).PubMedCrossRefGoogle Scholar
  24. 24.
    Garrett, E.R.; Drug Action and Assay by Microbial Kinetics, in Jucker, E., ed., Progress in Drug Research 15, 271–352, 1971, Birkhaüser Verlag, Basel und Stuttgart.Google Scholar
  25. 25.
    Dettli, L.: Pharmakokinetik bei repetierter Arzneimittelapplikation, in: Klinische Pharmakologie und Pharmakotherapie, Kuemmerle, H.P., Garrett, E.R. and Spitzy, K.H. (eds.), Urban and Schwarzenberg Verlag, Munich, pp. 59–65, 1971.Google Scholar
  26. 26.
    Doluisio, J.T., La Piana, J.C. and Dittert, L.W., J. Pharm. Sci., 60, 715, 1971.PubMedCrossRefGoogle Scholar
  27. 27.
    Kostenbauder, H.B., Portnoff, J.B. and Swintosky, J.V., J. Pharm. Sci., 51, 1084, 1962.PubMedCrossRefGoogle Scholar
  28. 28.
    Evans, P.A.P., Manley, K.A. and McKusick, V.A., Br. Med. J., 2, 485, 1960.PubMedCrossRefGoogle Scholar
  29. 29.
    Kretchmer, N., Pediatrics, 23, 606, 1959.PubMedGoogle Scholar
  30. 30.
    Dettli, L., Spring, P., and Ryter, S., Acta. Pharmacol. 29 (Suppl. 3) 211, 1971.Google Scholar
  31. 31.
    Kunin, C.M., Glazko, A.J., Finland, M., J. Clin. Invest. 38, 1498, 1959.PubMedCrossRefGoogle Scholar
  32. 32.
    Levi, A.J., Sherlock, S. and Walker, D., Lancet, June 15, 1275, 1968.CrossRefGoogle Scholar
  33. 33.
    Jusko, W.J.: Pharmacokinetic management of antibiotic therapy, Clinical Pharmacokinetics, A Symposium, Ed. G. Levy, Am. Pharm. Assoc, Oct. 1974.Google Scholar
  34. 34.
    Wagner, J.G. and Nelson, E., J. Pharm. Sci., 52, 610, 1963;PubMedCrossRefGoogle Scholar
  35. 34a.
    Wagner, J.G. and Nelson, E., J. Pharm. Sci., 53, 1392, 1964.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Edward R. Garrett
    • 1
  • Peter H. Hinderling
    • 1
  1. 1.College of Pharmacy, Health CenterUniversity of FloridaGainesvilleUSA

Personalised recommendations