Adverse Reactions under Intermittent Rifampicin Regimens
Adverse reactions to rifampicin under intermittent regimens are more frequent with high 1200 mg doses of rifampicin than with low 600 mg doses. The incidence of adverse reactions was noted in 25% out of 324 patients being studied. It was with 6% during the low dosage and 28% with higher doses of rifampicin given intermittently. Termination of treatment due to toxicity to rifampicin was necessary in 1% and 10% respectively. The adverse reactions were of variable form and intensity. Five types of adverse reaction syndromes were encountered. The frequency of adverse reactions in intermittent therapy depends on many factors such as preceding daily therapy, size of dosage, group of patients, their state and clinical conditions. It can be accepted that they are immunologically induced.
KeywordsAdverse Reaction Daily Regimen Intermittent Treatment Intermittent Therapy Intermittent Regimen
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