Clinical Trial of a Monovalent Benzylpenicilloyl Hapten Inhibitor (Ro 6–0787) In Penicillin Allergy

  • M. C. Vonlanthen
  • F. Jeunet
  • K. H. Schulz
  • J. P. Girard
Part of the Chemotherapy book series (CT, volume 4)


Inhibition of antibody and antibody-dependant immune reactions by monovalent haptens is a well known phenomenonv(1) and has been suggested for prevention of immediate allergic reactions(1,2,3). The practical application of an inhibiting monovalent penicilloyl hapten to prevent immediate-type allergic reaction to penicillin in patients allergic to this group of drugs was initiated by de Weck and Schneider(4) and by de Weck and Girard(5) a few years ago. Based on experimental data indicating the a N-e-benzyl-a-formyl-L-lysine derivative (Ro 6–0787 or BPO-FLYS) is structurally optimally fitting the antibody combining sites of antibenzylpenicillin-anti-bodies, and efficiently inhibits various antibody-rdependant allergic reactions in animals sensitized to penicillin4(4).


Allergic Reaction Positive Skin Test Penicillin Allergy Passive Hemagglutination Reaction Allergiques 


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. C. Vonlanthen
    • 1
  • F. Jeunet
    • 1
  • K. H. Schulz
    • 1
  • J. P. Girard
    • 1
  1. 1.Division of Immunology and Allergy, Department of MedicineUniversity of Geneva Medical SchoolGenevaSwitzerland

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