Side-Effects of High-Dose Dicloxacillin Therapy

  • H. Köhler
  • T. R. Weihrauch
  • W. Prellwitz
  • D. Höffler
Part of the Chemotherapy book series (CT, volume 4)


The limiting toxic factor in high-dose penicillin therapy seems to be the effect on the central nervous system. In comparison with other semisynthetic penicillins dicloxacillin is the most neurotoxic in rabbits, as previous studies have shown (11). In rabbits neurotoxic serum levels also produce hemolysis. Cloxacillin, oxacillin and carbenicillin showed to be less neurotoxic and did not induce hemolysis. The present study was undertaken to determine whether in high-dose dicloxacillin therapy hemolysis is likely in man and is, therefore, of clinical importance.


Uric Acid Interstitial Nephritis Direct Toxic Effect Free Hemoglobin Reversible Increase 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. Köhler
    • 1
  • T. R. Weihrauch
    • 1
  • W. Prellwitz
    • 1
  • D. Höffler
    • 1
  1. 1.I. and II. Medizinische Klinik und PoliklinikJohannes Gutenberg-UniversitätMainzFederal Republic of Germany

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