Possible Mechanisms in Pathogenesis of Nitrofurantoin-Induced Lung Disease
The mechanisms operating in pathogenesis of allergic reactions to drugs have received relatively little attention (with the notable exception of the production of anaphylaxis by the penicillins about which there is considerable literature) and this is surprising since it is estimated that some 5% of hospital medical admissions in the United States are due to drug reactions and over 15% of patients in hospital suffer at least one such adverse reaction (Report of the International Conference on Adverse Reactions Reporting Systems, 1971). Allergic reactions are not the commonest type of drug reaction but are often severe; they are those untoward reactions mediated by immunological mechanisms as opposed to overdosage, toxicity, idiosyncrasy, side effects and interaction with other drugs.
KeywordsAlveolar Macrophage Autologous Serum Lymphocyte Transformation Acute Reaction Pulmonary Eosinophilia
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