Advertisement

Studies on Tissue Distribution of Antibiotics — An Attempt to Estimate Tissue Levels from Macro-Organisms

  • Jingoro Shimada
  • Yasushi Ueda
  • Motofumi Saigusa
  • Ryoichi Tsukuda
Part of the Chemotherapy book series (CT, volume 4)

Abstract

We have designed a quantitative assay method (to be tentatively called the tissue scanning method) of the levels of drugs in tissue through determination of the degrees of blackening in macro-AR with the absorbance values using the auto-scanning microscope photometer (SMP) on-line system in which a computer was incorporated. In this report, we will describe the details of this method and the results of our quantitative determination of local levels of antibiotics in the infected kidneys of mice with experimental pyelonephritis using this method.

Keywords

Renal Cortex Necrotic Focus Pipemidic Acid Infected Kidney Warm Water Bath 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Jingoro Shimada
  • Yasushi Ueda
    • 1
  • Motofumi Saigusa
    • 1
  • Ryoichi Tsukuda
    • 2
  1. 1.Department of Internal Medicine, School of MedicineThe Jikei UniversityMinato-ku, TokyoJapan
  2. 2.Takeda Research LaboratoryJuso, OsakashiJapan

Personalised recommendations