Studies on Tissue Distribution of Antibiotics — An Attempt to Estimate Tissue Levels from Macro-Organisms
We have designed a quantitative assay method (to be tentatively called the tissue scanning method) of the levels of drugs in tissue through determination of the degrees of blackening in macro-AR with the absorbance values using the auto-scanning microscope photometer (SMP) on-line system in which a computer was incorporated. In this report, we will describe the details of this method and the results of our quantitative determination of local levels of antibiotics in the infected kidneys of mice with experimental pyelonephritis using this method.
KeywordsRenal Cortex Necrotic Focus Pipemidic Acid Infected Kidney Warm Water Bath
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