The Excretion of Hetacillin Methoxymethyl Ester (BL-P1761) into the Prostatic Fluid of the Dog
The lipid-soluble methoxymethyl ester of hetacillin was found to penetrate well into the prostatic fluid of dogs. The prostatic fluid ampicillin concentrations following intravenous infusion of the ester were approximately 15 times higher than following intravenous infusion of ampicillin in equivalent amounts and were approximately 1/2 of the simultaneous blood concentrations. The bactericidal effect of the prostatic fluid following hetacillin ester administration is demonstrated in vitro.
KeywordsIntravenous Infusion Constant Infusion Recurrent Urinary Tract Infection Lipid Solubility Ampicillin Activity
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