The Excretion of Hetacillin Methoxymethyl Ester (BL-P1761) into the Prostatic Fluid of the Dog

  • Torben B. Kjaer
  • Paul O. Madsen
Part of the Chemotherapy book series (CT, volume 4)


The lipid-soluble methoxymethyl ester of hetacillin was found to penetrate well into the prostatic fluid of dogs. The prostatic fluid ampicillin concentrations following intravenous infusion of the ester were approximately 15 times higher than following intravenous infusion of ampicillin in equivalent amounts and were approximately 1/2 of the simultaneous blood concentrations. The bactericidal effect of the prostatic fluid following hetacillin ester administration is demonstrated in vitro.


Intravenous Infusion Constant Infusion Recurrent Urinary Tract Infection Lipid Solubility Ampicillin Activity 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Torben B. Kjaer
    • 1
  • Paul O. Madsen
    • 1
  1. 1.Section of Urology, Veterans Administration Hospital and Department of SurgeryUniversity of Wisconsin School of MedicineMadisonUSA

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