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A Pharmacokinetic Study of the Combination Rifampicin Plus Trimethoprim in Man

  • W. Brumfitt
  • V. M. Moss
  • E. Brooker
  • J. M. T. Hamilton-Miller
Part of the Chemotherapy book series (CT, volume 4)

Abstract

Previous work in this laboratory (Kerry, Hamilton-Miller and Brumfitt 1975a,b) has shown that a combination of rifampicin (rif) and trimethoprim(tm) will inhibit virtually all common pathogenic bacteria. The combination has the added advantage of acting synergistically against several genera, notably streptococci and all species of proteus. Secondly, it suppresses the emergence of resistance to rifampicin. In view of these encouraging findings, we have now undertaken a pharmacokinetic study to determine whether rif and tm interfere with one another’s handling in man.

Keywords

Urinary Excretion Bacillus Pumilis Aspartate Transaminase Encourage Finding Tryptone Soya Agar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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  4. Kerry, D.W., Hamilton-Miller, J.M.T. & Brumfitt, W. 1975a J. Antimicrob.Chemother., 1 in press.Google Scholar
  5. Kerry, D.W., Hamilton-Miller, J.M.T. & Brumfitt, W. 1975b These Proceedings.Google Scholar
  6. Schwartz, D.E. & Rieder, J. 1970 Chemotherapia, 15, 337.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. Brumfitt
    • 1
  • V. M. Moss
    • 1
  • E. Brooker
    • 1
  • J. M. T. Hamilton-Miller
    • 1
  1. 1.The Royal Free HospitalHampstead, LondonUK

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