Antibiotic Concentrations in Human Interstitial Fluid

  • James S. Tan
Part of the Chemotherapy book series (CT, volume 4)


Serum concentrations of antibiotics have been used as a clinical guide to adequacy of therapy. However, these values do not necessarily reflect the antimicrobial activities outisde the vascular compartment. Levels of antimicrobial agents in some extravascular fluids such as aqueous humor, synovial fluids, cerebrospinal fluid and saliva, have been reported. However, these may not represent the actual interstitial fluid activities because of the specialized nature of the membranes and secretory mechanisms of the tissues involved.


Aqueous Humor Interstitial Fluid Antibiotic Concentration Penicillin Versus Vascular Compartment 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • James S. Tan
    • 1
  1. 1.Akron City HospitalAkronUSA

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