Investigation of the Gastrointestinal Absorption of Ampicillin, Cephalexin and Pivampicillin
In continuation of our investigations concerning the absorption of antibiotics in patients with partial gastrectomy (Lode et al., 1973), we occupied ourselves with the exact gastrointestinal location of ß-Lactam-antibiotic absorption. Since the time when Hogben et al. (1958) had laid the experimental cornerstone, it became evident that numerous substances, such as antibiotics, can be absorbed by way of gastric mucosa. On the basis of rapid and almost complete absorption of the cephalexin-monohydrate in normal test individuals, and based upon the limited invasion property in cases of partial gastrectomy, an absorption of this antibiotic by way of gastric mucosa had been suspected; Ampicillin-trihydrate, however, showed markedly delayed as well as limited characteristics of absorption which remained unchanged in spite of partial gastrectomy.
KeywordsGastric Mucosa Partial Gastrectomy Gastrointestinal Absorption Urine Recovery Urine Elimination Rate
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