Effect of Recumbency on Erythromycin Absorption
During a concurrent bioavailability study of pivmecillinam, the results of which have been reported elsewhere in the proceedings of this Congress (1) we obtained significantly different mean plasma concentrations of mecillinam compared with those found by another centre investigating this compound. One possible cause for this difference is that supine subjects were studied by the other group, whilst we had studied subjects performing their normal working activities. This finding prompted us to undertake the present study. This was designed to ascertain whether the activity of the subject affected the absorption of erythromycin.
KeywordsUrinary Excretion Peak Plasma Concentration Small Intestinal Transit Ethyl Succinate Supine Subject
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