Effect of Recumbency on Erythromycin Absorption

  • R. L. Parsons
  • Gillian M. Paddock
Part of the Chemotherapy book series (CT, volume 4)


During a concurrent bioavailability study of pivmecillinam, the results of which have been reported elsewhere in the proceedings of this Congress (1) we obtained significantly different mean plasma concentrations of mecillinam compared with those found by another centre investigating this compound. One possible cause for this difference is that supine subjects were studied by the other group, whilst we had studied subjects performing their normal working activities. This finding prompted us to undertake the present study. This was designed to ascertain whether the activity of the subject affected the absorption of erythromycin.


Urinary Excretion Peak Plasma Concentration Small Intestinal Transit Ethyl Succinate Supine Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Parsons, R. L., Hossack, G. M., and Paddock, G. M. Plasma profile and urinary excretion of mecillinam after pivmecillinam. Proceedings of the 9th International Congress of Chemotherapy, 1975 in press.Google Scholar
  2. 2.
    Grove, D. C., and Randall, W. A. Assay methods of antibiotics: A laboratory manual. Medical Encyclopedia Inc., New York (1955).Google Scholar
  3. 3.
    Levy, G. Effect of bed rest on distribution and elimination of drugs. J. Pharm. Sci. 56, 928–929 (1967).PubMedCrossRefGoogle Scholar
  4. 4.
    Schmidt, H. and Roholt, K. Penicillin serum concentrations in relation to exercise. Act. Path. et Microbiol. Scandinav. 68, 396–400 (1966).Google Scholar
  5. 5.
    Davis, S. S. Scientific principles in design of drug dosage formulations. British Medical Journal, 1, 102–106 (1972).PubMedCrossRefGoogle Scholar
  6. 6.
    Chisholm, G. D., Waterworth, P. M., Calnan, J. S., and Garrod, L. P. Concentration of antibacterial agents in interstitial fluid. British Medical Journal, 1, 569–573 (1973).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. L. Parsons
    • 1
  • Gillian M. Paddock
    • 1
  1. 1.Department of Clinical PharmacologyGuy’s Hospital Medical SchoolLondonUK

Personalised recommendations