Serum Levels of Nalidixic Acid in Patients with Impaired Renal Function
Parallel chemical and microbiological determinations of serum levels of nalidixic acid have shown that with doses of nalidixic acid of 4 g per day administered as antibacterial treatment to patients with cystopyelone-phritis and reduced renal function (serum creatinine 1,5–13.0 mg/100ml) the serum levels of this substance were significantly higher than in patients with normal renal function. Despite plasma values between 40 and 70 mcg/ml found with the microbiological method and correspondingly higher ones with the chemical method there was no evidence of side effects even when the treatment was continued for a longer period of time, i.e. for up to two weeks. The germs were sensitive to the substance, and the treatment had a good clinical effect.
KeywordsRenal Function Renal Insufficiency Normal Renal Function Impaired Renal Function Nalidixic Acid
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