Sisomicin: Serum Half-Life and Distribution Space in Patients with Normal and Impaired Renal Function
Sisomicin, a new aminoglykoside antibiotic, is now beeing introduced for clinical trials in the treatment of urinary tract infections. The purpose of this study was to determine some data of the pharmacokinetics in patients with normal and impaired renal function and to develop guidlines for appropriate dosage regimens for patients with renal insufficiency and in case of hemodialysis.
KeywordsSerum Creatinine Renal Insufficiency Normal Renal Function Impaired Renal Function Plasma Clearance
Unable to display preview. Download preview PDF.
- 1.Black, J., Calesnick, B., Williams, D., Weinstein, M. J.: Pharmacology of gentamicin, a new broad-spectrum antibiotic; Antimicrob. Ag. Chemother: 138, 1963.Google Scholar
- 2.Grodon, R. C., Regamey, W. M., Kirby, M.: Serum proteinbinding of the aminoglycoside antibiotics. Antimicrob. Ag. Chemother: 214, 1972.Google Scholar
- 5.Naber, K. G., Westerfelder, S. R., Madsen, P. O.: Pharmacokinetics of the aminoglycoside antibiotic tobramycin in humans. Antibmicrob. Ag. Chemother. 3: 469, 1973.Google Scholar
- 6.Sigman, E. M., Elwood, C. M. and Knox, F.: The measurement of glomerular filtration rate in man with sodium iothalamate131 I (Conray). J. Nucl. Med. 7: 60, 1965.Google Scholar