The In Vivo Significance of Antibiotics in the Tissues

  • H. Mattie
Part of the Chemotherapy book series (CT, volume 4)


Pharmacology as a way of thinking can contribute much to practical medicine. One of these contributions is that it has been shown in animal and in vitro experiments that for nearly all drugs a quantitative relation-ship exists between dose, or better concentration, and effect. Moreover, concentrations lower than so called threshold concentrations exert no effect at all, while at the other end a maximal effect can be found which depends on the characteristics of the interaction of drug and receptor. This maximal effect cannot be exceeded by much higher concentrations.


Serum Concentration Minimal Inhibitory Concentration Tissue Concentration Pharmacokinetic Model Fibrin Clot 
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  1. M. Barza and L. Weinstein, J. of Inf. Dis., 129, p. 73, 1974.CrossRefGoogle Scholar
  2. H. Mattie et al., J. of Inf. Dis., 128, 170, 1973.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. Mattie
    • 1
  1. 1.Dept. of Clinical PharmacologyAcademisch ZiekenhuisLeidenThe Netherlands

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