The Use of Gentamicin in Patients with Impaired Renal Function
Gentamicin is a useful antibiotic for serious gram negative infection, but there is fear of side-effects particularly if renal failure is present. Careful analysis of the literature shows a low incidence of nephrotoxicity, normally associated with concomitant cephalosporin administration and always reversible (Palco et al. 1969; Wilfert et al. 1971, Pillastre et al. 1973; Noone et al. 1974). Comparison of a conventional renal function related dosage schedule (Gingell and Waterworth; 1968) and a nomogram method (Cham et al. 1972) has been made in patients with varying degrees of renal impairment. We studied the efficacy of gentamicin in curing infection, its ability to obtain satisfactory blood levels, and its effect on renal function.
KeywordsUrea Creatinine Pneumonia Bacillus Pseudomonas
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- Noone, P. et al (1974) ibid, i, 477.Google Scholar