The Use of Gentamicin in Patients with Impaired Renal Function

  • J. L. Anderton
  • Elizabeth Hanson
  • J. A. Raeburn
Part of the Chemotherapy book series (CT, volume 4)

Abstract

Gentamicin is a useful antibiotic for serious gram negative infection, but there is fear of side-effects particularly if renal failure is present. Careful analysis of the literature shows a low incidence of nephrotoxicity, normally associated with concomitant cephalosporin administration and always reversible (Palco et al. 1969; Wilfert et al. 1971, Pillastre et al. 1973; Noone et al. 1974). Comparison of a conventional renal function related dosage schedule (Gingell and Waterworth; 1968) and a nomogram method (Cham et al. 1972) has been made in patients with varying degrees of renal impairment. We studied the efficacy of gentamicin in curing infection, its ability to obtain satisfactory blood levels, and its effect on renal function.

Keywords

Urea Creatinine Pneumonia Bacillus Pseudomonas 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chan, R.A., Benner, E.J., Hoeprich, M.D. (1972). Annals of Internal Medicine, 76, 773.PubMedGoogle Scholar
  2. Palco, F.G., Smith, H.M., and Arcieri, G.M. (1969). J. Infect. Dis., 119, 406.CrossRefGoogle Scholar
  3. Pillastre, J.P. et al (1973) British Medical Journal, ii, 396.CrossRefGoogle Scholar
  4. Gingell, JVC, and Waterworth, P.M. (1968) ibid, ii, 19.CrossRefGoogle Scholar
  5. Noone, P. et al (1974) ibid, i, 477.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. L. Anderton
    • 1
  • Elizabeth Hanson
    • 1
  • J. A. Raeburn
    • 1
  1. 1.Departments of Medicine and Human GeneticsWestern General HospitalEdinburghUK

Personalised recommendations