Prolonged Excretion of Gentamicin in Patients with Normal Renal Function
Gentamycin, like the other aminoglycosides, is potentially oto- and nephrotoxic. Despite ten years of clinical experiance it is still not possible to predict the occurrence of oto- and/ or nephrotoxic incidences in a given patient. Vestibular calamities occur unexpectedly, sometimes considerable time after therapy has been discontinued (Jao and Jackson, -64). Renal function impairment, although often slight and transient, seems to be more frequent than was originally supposed (Mosegaard et al., -75). A better understanding of the pharmacokinetic properties of the drug is a necessity to ensure optimal therapeutic effect while at the same time avoiding the oto- and nephrotoxic incidences.
KeywordsNormal Renal Function Urine Concentration Renal Parenchyma Single Subcutaneous Injection Prolonged Excretion
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- Alfthan, O., Renkonen, O, V. Sivonen, A. Acta path. microbial. scand. Section B. 1973, 81, S92.Google Scholar
- Jao, R. L., Jackson, G. G. Antimicrob. Ag. Chemother. 1964, 4, 148.Google Scholar
- Mosegaard, A., Welling, P. G., Madsen, P. O. Antimicrob. Ag. Chemother. 1975, 7, 328.Google Scholar
- Ramirez-Ronda, C. H., Holmes, R. K., Sandford, J. P. Antimicrob. Ag. Chemother. 1975, 7, 239.Google Scholar