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The Effect of pH on the Transport of Oligosaccharidic Antibiotics across a Membrane Model System

  • L. Favalli
  • M. C. Chiari
  • A. Rozza
  • F. Piccinini
Part of the Chemotherapy book series (CT, volume 4)

Abstract

It has been mainly reported that drugs are transported into the cell by simple or facilitated diffusion and generally not by active transport (1). Since biological membranes can be seen as a protein-coated lipidic bilayer, it has been assumed that the most important property which enables molecules to be transferred across the membrane is their lipophylic character. As far as antibiotics are concerned, it has been postulated that the same property is also requested for bacterial cell permeation. On the basis of this assumption, it has been suggested that a relationship exists between the water-to-oil partition coefficient and the antibacterial activity (2–3), although the chemical composition of the mammalian cell membrane is different from that of bacterial cells.

Keywords

Antibacterial Activity Organic Phase Partition Coefficient Water Phase Prostatic Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • L. Favalli
    • 1
  • M. C. Chiari
    • 1
  • A. Rozza
    • 1
  • F. Piccinini
    • 1
  1. 1.Cattedra di Saggi e Dosaggi FarmacologiciUniversità di PaviaItaly

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