Aging and Antimicrobial Therapy
Progressive glomerulosclerosis in aging rats induces atrophic changes of the tubules. This phenomenon may explain the results of radionuclides clearances and slower elimination of amoxycillin both in men and rats with aging. Diminished active tubular excretion of amoxycillin with aging seems not to be compensated by adaptive extrarenal routes of elimination. On the contrary flucloxacillin does not show deterioration of elimination from blood in aging rats.
KeywordsGlomerular Filtration Rate Antimicrobial Therapy Tubular Function Atrophic Change Slow Elimination
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