Aging and Antimicrobial Therapy

  • P. L. Oe
  • J. Verhoef
Part of the Chemotherapy book series (CT, volume 4)


Progressive glomerulosclerosis in aging rats induces atrophic changes of the tubules. This phenomenon may explain the results of radionuclides clearances and slower elimination of amoxycillin both in men and rats with aging. Diminished active tubular excretion of amoxycillin with aging seems not to be compensated by adaptive extrarenal routes of elimination. On the contrary flucloxacillin does not show deterioration of elimination from blood in aging rats.


Glomerular Filtration Rate Antimicrobial Therapy Tubular Function Atrophic Change Slow Elimination 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. L. Oe
    • 1
  • J. Verhoef
    • 1
  1. 1.Department of Internal Medicine, Academic HospitalFree UniversityAmsterdamThe Netherlands

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