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Aging and Antimicrobial Therapy

  • Chapter
Pharmacology of Antibiotics

Part of the book series: Chemotherapy ((CT,volume 4))

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Summary

Progressive glomerulosclerosis in aging rats induces atrophic changes of the tubules. This phenomenon may explain the results of radionuclides clearances and slower elimination of amoxycillin both in men and rats with aging. Diminished active tubular excretion of amoxycillin with aging seems not to be compensated by adaptive extrarenal routes of elimination. On the contrary flucloxacillin does not show deterioration of elimination from blood in aging rats.

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References

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Academic Hospital, Free University, Amsterdam, The Netherlands

    P. L. Oe & J. Verhoef

Authors
  1. P. L. Oe
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  2. J. Verhoef
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Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

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© 1976 Plenum Press, New York

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Oe, P.L., Verhoef, J. (1976). Aging and Antimicrobial Therapy. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_14

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  • DOI: https://doi.org/10.1007/978-1-4684-3123-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3125-4

  • Online ISBN: 978-1-4684-3123-0

  • eBook Packages: Springer Book Archive

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