Antimicrobial Therapy in Patients on Haemodialysis

  • J. Verhoef
  • P. L. Oe
Part of the Chemotherapy book series (CT, volume 4)


In this study pharmacokinetic data of 5 antibiotics (amoxycillin, gentamycin, cephalothin, lincomycin and flucloxacillin), frequently used in patients with terminal renal failure undergoing haemodialysis, were compared with similar data, obtained by propelling these antimicrobials through an isolated artificial kidney system. There is evidence, that the one-compartment model is suitable for describing the pharmacokinetics of antimicrobials in patients undergoing haemodialysis. This is especially valid for getting more insight in the main routes of elimination of the antibiotic from blood during haemodialysis in uraemic patients.


Antimicrobial Therapy Uraemic Patient Artificial Kidney Average Clearance Terminal Renal Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. Verhoef
    • 1
  • P. L. Oe
    • 1
  1. 1.Department of Internal Medicine, Academic HospitalFree UniversityAmsterdamThe Netherlands

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