Antimicrobial Therapy in Patients on Haemodialysis
In this study pharmacokinetic data of 5 antibiotics (amoxycillin, gentamycin, cephalothin, lincomycin and flucloxacillin), frequently used in patients with terminal renal failure undergoing haemodialysis, were compared with similar data, obtained by propelling these antimicrobials through an isolated artificial kidney system. There is evidence, that the one-compartment model is suitable for describing the pharmacokinetics of antimicrobials in patients undergoing haemodialysis. This is especially valid for getting more insight in the main routes of elimination of the antibiotic from blood during haemodialysis in uraemic patients.
KeywordsAntimicrobial Therapy Uraemic Patient Artificial Kidney Average Clearance Terminal Renal Failure
Unable to display preview. Download preview PDF.
- Blaufox, M. (1972) Progress in Nuclear Medicine, 2.Google Scholar
- Cutler, R.E., Christopher, T.G., Forrey, A.W. and Blair, A.D. (1975) Kidney International, 7, s-16.Google Scholar
- Kirby, W.M.M., De Maine, J.B. and Scott Serrill, W. (1971) Postgraduate Med. J., 41.Google Scholar
- Oe, P.L. (1974) Thesis “Antimicrobial therapy and renal failure”. Academische Pers, Amsterdam, 100.Google Scholar
- Reidenberg, M.M. (1971) Renal function and drug action, W.B. Saunders Co, 70.Google Scholar