Tissue Binding of Antibiotics
Two groups of antibiotics, the polymyxins and the polyenes, owe their antimicrobial activity to their ability to bind to and disrupt microbial cell membranes. The polymyxins bind to acid phospholipids in gram-negative bacteria, whereas, the polyenes attach to sterols in membranes of fungi and mycoplasma. These drugs also bind to cell membranes of vertebrates and may not only owe their toxicity to this effect, but also may be largely inactivated at membrane-binding sites.
KeywordsAminoglycoside Antibiotic Tissue Binding Acid Phospholipid Nephrotoxic Effect Intracellular Substance
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