Comparative Study of the Inactivation of Isoniazid in Africans and Europeans

  • E. Bergogne-Berezin
  • J. Modai
Part of the Chemotherapy book series (CT, volume 3)

Abstract

The determination of concentrations of free isoniazid (INH) in the blood of patients treated for tuberculosis has not yet become part of routine examination procedures; for the last 15 years, this test has nevertheless greatly helped to gain a deeper knowledge of the 2 classes of slow and rapid inactivators of isoniazid into which humans are divided, the distribution of these types of inactivators into various ethnical groups studied since 1960 by various authors (Armstrong, Harris, Jeanes, etc.), the genetic determinism of the phenotypes of inactivation determined by Evans.

Keywords

Tuberculosis Isoniazid MYcobacterium 

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • E. Bergogne-Berezin
    • 1
  • J. Modai
    • 1
  1. 1.Bichat and Claude Bernard HospitalsParisFrance

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