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Meclocycline, an Antibiotic for Topical Use

  • Loris Jacopo Bononi
Part of the Chemotherapy book series (CT, volume 3)

Abstract

Meclocycline or 7-chloro-6-methylene-5-hydroxytetracycline belongs to the class of the 6-methylenetetracyclines (1). Meclocycline is one of the most active tetracyclines in vitro. Against strains of Shigella and Salmonella in vitro studies report meclocycline to be equal or superior to streptomycin and chloramphenicol (2). Several investigations have confirmed the in vitro broad spectrum activity of meclocycline (2, 4, 16, 19, 24, 23), and pointed out a marked antitreponema activity in vitro and an antiborrelia activity in vivo (3). The in vivo activity of meclocycline per os against Staphylococcus aureus infection has been negative. The in vivo activity of meclocycline parenterally against Staphylococcus aureus infection has been comparable to that of tetracycline (26). In rats, oral meclocycline is very active on aerobia, coliforms and (which is unusual for a tetracycline) also on mycetes (7). Meclocycline is exceedingly insoluble in water, poorly soluble in serum, very poorly absorbed from the gastrointestinal tract and not absorbed through the skin (4, 8, 9). Meclocycline in the chloroform/water system appears to be somewhat more lipophilic than other tetracyclines, except doxycycline (23). The oral absorption of meclocycline would expect to be better, in consequence of this fact, however, experiments in animals and in man show a very poor gastrointestinal absorption (6, 11, 26) and a possible explanation is offered by the very high mucin binding found in vitro (4).

Keywords

Alimentary Tract Oral Absorption Broad Spectrum Activity Antibacterial Spectrum Allergical Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Loris Jacopo Bononi
    • 1
  1. 1.University of TurinItaly

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