Contamination of Antiseptics and Use of Preservatives

  • D. A. Norton
Part of the Chemotherapy book series (CT, volume 3)


Antiseptic substances such as benzalkonium chloride, chlorhexidine and organic mercurial compounds are also employed as antimicrobial preservatives in pharmaceutical preparations. Some of these substances have been implicated in accidental contamination involving loss of preservative efficiency and infection hazards particularly from organisms of Pseudomonas species.


Ophthalmic Solution Benzalkonium Chloride Pharmaceutical Journal Contact Lens Solution Absolute Standard 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anon (1964) British Medical Journal (ii), 1513.Google Scholar
  2. 2.
    British Pharmaceutical Codex 1963, Supplement 1966 p. 77. ( The Pharmaceutical Press, London ).Google Scholar
  3. 3.
    Brown, M.R.W. (1968). Journal of Pharmaceutical Sciences, 57 (3) 389–392.CrossRefGoogle Scholar
  4. 4.
    Davies, D.J.G. and Norton, D.A. (1975). Journal of Pharmacy and Pharmacology, 27 (5), 383–4.PubMedCrossRefGoogle Scholar
  5. 5.
    Department of Pharmaceutical Sciences, Pharmaceutical Society of Great Britain, Laboratory Reports P69/10, P69/14 and P70/5.Google Scholar
  6. 6.
    Hugo, W.B. and Foster, J.H.S. (1964). Journal of Pharmacy and Pharmacology 16 Supplement 124T - 126T.Google Scholar
  7. 7.
    Hugo, W.B. and Wilson, J.V. (1970). Pharmaceutical Journal, 204, 714.Google Scholar
  8. 8.
    Kelsey, J.C. and Maurer, Isobel M. (1974). Pharmaceutical Journal 213, 528–530.Google Scholar
  9. 9.
    Linton, K.B. and George, E. (1966), Lancet (i) 1353–55.Google Scholar
  10. 10.
    McBride, R.J. and Mackie, Mary A.L. (1974). Journal of Pharmacy and Pharmacology, 26, 899–900.PubMedCrossRefGoogle Scholar
  11. 11.
    Norton, D.A., Davies, D.J.G., Richardson, N.E., Meakin, B. J. and Keall, A. (1974). Journal of Pharmacy and Pharmacology, 26 841–846.PubMedCrossRefGoogle Scholar
  12. 12.
    Richards, R.M.E. (1975). Journal of Pharmacy and Pharmacology, 27 (5), 381–2.PubMedCrossRefGoogle Scholar
  13. 13.
    Richards, R.M.E. and McBride, R.J. (1971). British Journal of Ophthalmology, 55, 734.PubMedCrossRefGoogle Scholar
  14. 14.
    Speller, D.C.E., Stephens, M.E. and Viant, A.C. (1971). (Letter to Editor) Lancet, (i) 798–9.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • D. A. Norton
    • 1
  1. 1.School of Pharmacy and PharmacologyUniversity of BathUK

Personalised recommendations